How I treat heparin-induced thrombocytopenia

How I treat How I treat heparin-induced thrombocytopenia

Heparin-induced thrombocytopenia is a prothrombotic adverse drug effect induced by platelet-activating antibodies against multimolecular complexes of platelet factor 4 and heparin. Diagnosis rests on a clinical assessment of disease probability and laboratory testing. Management involves immediate discontinuation of heparin and initiation of an alternative anticoagulant. Because of the frequenc...

How I treat heparin-induced thrombocytopenia and thrombosis.

How I treat How I treat heparin-induced thrombocytopenia and thrombosis

Heparin-induced thrombocytopenia (HIT) is one of the most common and potentially devastating of immune-mediated drug reactions.1 The clinical manifestations of this disorder are initiated by antibodies directed against platelet factor 4 (PF4), which becomes an antigenic target when bound to heparin. The immune complex binds to the Fc RII receptors on circulating platelets and induces platelet a...

Heparin induced thrombocytopenia

Abstract Background and Objectives Heparin is still a commonly used anticoagulant in prophylaxis and treatment of thromboembolic events. Heparin-induced thrombocytopenia (HIT) is a life-threating adverse drug reaction of heparin. The diagnosis of HIT is made based on two important criteria, firstly clinical evaluation and secondly laboratory testing. In this comprehensive review, the authors w...

How I Treat How I treat thrombocytopenia in pregnancy

A mild thrombocytopenia is relatively frequent during pregnancy and has generally no consequences for either the mother or the fetus. Although representing no threat in the majority of patients, thrombocytopenia may result from a range of pathologic conditions requiring closer monitoring and possible therapy. Two clinical scenarios are particularly relevant for their prevalence and the issues r...